When the percentages of DX5+ NK cells were determined after 7 days of gingiva cell culture, there was a consistent decline in the percentages of DX5+ cells within WT mice fed with HFCD or KC mice fed with CD as well as HFCD, exhibiting the following profiles (WT/CD > WT/HFCD > KC/CD > KC/HFCD) (Figure 2B), the most severe decline was seen in KC mice fed with HFCD (Figure 2B). The gene discussed is CALCA; the disease is keratoconus.