In addition, we demonstrate that at the precancerous stage of tumorigenesis, there is a significant elevation in the secreted inflammatory cytokines by gingival cells; however, at the cancerous stage, there is a severe decrease in IFN-γ secretion by the gingival cells from tumor-bearing mice which is restored by a single injection of super-charged NK cells in the presence and absence of feeding with AJ2. The gene discussed is IFNG; the disease is neoplasm.