The main genes mutated in pancreatic cancer include KRAS2, p16/CDKN2A, TP53, and SMAD4/DPC4 which are accompanied by a substantial genomic and transcriptomic alterations that facilitate cell cycle deregulation, tumor cell survival, invasion, and metastases (28, 29). Here, CDKN2A is linked to familial pancreatic carcinoma.