When the gingival cells from hu-BLT mice were cultured in the presence of IL-2 and the secretion of IFN-γ and IL-8 were determined (Figures 3E–J), there was a significantly lower secretion of IFN-γ from the oral gingiva cells of pancreatic tumor-bearing mice as compared to non-tumor-bearing healthy mice (Figures 3E–G). Here, CXCL8 is linked to pancreatic neoplasm.