PDCD1 and Hodgkins lymphoma: Because classical Hodgkin lymphoma has a high ORR to PD-1 blockade, these data may suggest that non-T responses also play important roles in the effect of PD-1 blockade, which is supported by a study showing that after PD-1 blockade, genes implicated in cytolysis and natural killer cell function were upregulated in patients (283).