However, PD-L1 blockade had only a moderate effect on gene activation and chromatin accessibility in tumor-infiltrating T cells, including upregulation of a few functionally important genes (including granzyme and serpin genes) and dampened accessibility in limited motifs binding NFAT, NFAT:AP-1, TCF, and bZIP:IRF transcription factors. The gene discussed is CD274; the disease is neoplasm.