Metabolic competition or adaptation between tumor cells and T cells (114) may contribute to these contrasting pathways, and the paradoxical results in transplantation models: alloreactive donor T-cells in PD-L1-deficient GVHD mice had increased aerobic glycolysis and oxidative phosphorylation (116), whereas donor PD-L1-deficient T cells in wild-type mice had reduced aerobic glycolysis, oxidative phosphorylation, fatty acid metabolism, and cytokine production (117). Here, CD274 is linked to neoplasm.