Moreover, during tumor growth in a mouse model, although increased PD-1 and LAG-3 expression was accompanied by decreased T-cell effector function, enhancing fatty acid catabolism increased PD-1 expression and improved T-cell effector function; conversely, inhibiting fatty acid catabolism decreased PD-1 expression and impaired T-cell function (28). This evidence concerns the gene LAG3 and neoplasm.