The ORRs with PD-1/PD-L1 blockade as monotherapy in relapse/recurrence settings largely differ by disease entities; the ORR is close to 70% in classical Hodgkin lymphoma which frequently has 9p24 copy number alterations (202), ~40% in skin cancers, ~20% in lung cancers, ~25% in renal cancer, 13–23% in bladder cancer, and 13–16% in HNSCC. This evidence concerns the gene PDCD1 and Hodgkins lymphoma.