CD274 and Hodgkins lymphoma: However, a surprisingly high frequencies of decreased or absent expression of β2M/MHC class I (79% overall; 92% in PD-L1/L2 amplified cases) and MHC class II (67%) were found in 108 patients newly diagnosed with classical Hodgkin lymphoma (88% of patients had nodular sclerosis Hodgkin lymphoma; 82.5% were negative for Epstein-Barr virus) (281).