DAXX and thalassemia: Recent whole-exome (46) and whole-genome (72) sequencing of pancreatic NETs identified that the most commonly mutated genes in this tumor type are genes involved in chromatin remodeling, such as multiple endocrine neoplasia type 1 (MEN1), death domain-associated protein (DAXX), α-thalassemia/mental retardation syndrome, X-linked (ATRX) (46), and DNA repair genes MUTYH, CHEK2, and BRCA2 (72).