In right ventricular hypertrophy, the myocardium experiences a significant increase in wall thickness, a negative force-frequency, an increase in diastolic tension, downregulation of SERCA, upregulation of NCX, and upregulation of ANP (Varian et al., 2009), similar to changes that occur in left ventricular hypertrophy (Hasenfuss et al., 1994, 1996, 1999; Prestle et al., 1999). The gene discussed is NPPA; the disease is Right ventricular hypertrophy.