PACAP/PAC1 receptor transcripts are increased in specific limbic structures following RVS exposure; CNS PACAP signaling is anxiogenic and anorexic, and chronic stress-induced anxiety-related behaviors can be blocked by PAC1 receptor antagonists (Hammack et al., 2009; Lezak et al., 2014a,b; Missig et al., 2014; Roman et al., 2014). This evidence concerns the gene ADCYAP1R1 and Anxiety.