PAX7 and facioscapulohumeral muscular dystrophy: We found that PAX7 target gene repression significantly outperformed DUX4 target expression as a classifier of FSHD status (Pax7 AUC = 0.81, DUX4 AUC = 0.59, DeLong’s test: p < 5.7 × 10−6, Fig. 4a), indicating that in microarray data, PAX7 target gene repression is a more robust signature of FSHD skeletal muscle than DUX4 target gene expression.