DUX4 and facioscapulohumeral muscular dystrophy: Despite overlap between the three DUX4 signatures (28 genes shared between Geng et al.35 and Choi et al.34, 45 between Yao et al.10 and Geng et al.35 and 29 between Choi et al.34 and Yao et al.10), we see that RNA-seq-derived DUX4 upregulated target genes are only capable of discriminating FSHD biopsies from controls, if the biopsies were also profiled by RNA-seq.