RNASE3 and inflammation: Allergic asthma is a chronic inflammatory disorder of the airways with both systemic inflammation with increased levels of IgE and local eosinophilic inflammation with the release of eosinophilic granular proteins such as eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP).10,11 Elevated levels of EDN and ECP reflect eosinophilic activity in the lungs as well as severity and activity of asthma.12 The local eosinophilic inflammation in the airways is also reflected in the fraction of exhaled nitric oxide (FENO), which is increased in patients with allergic asthma.13,14