ORAI1 and Alzheimer disease: Although Ca2+-related genes as a category did not show significant overrepresentation of genes with aging changes that were countered by FKBP1b, the genes for two Ca2+-sensitive enzymes frequently associated with brain aging, neuronal plasticity, and AD, Cpn-1 (calpain-1) and Ppp3cc (calcineurin, Nixon et al., 1994; Rozkalne et al., 2011; Furman and Norris, 2014), as well as a Ca2+ release-activated Ca2+ channel (ORAI1) were altered by aging and restored by FKBP1b treatment (Table 3).