FKBP1B and memory impairment: In addition, to determine whether long-term (LT) FKBP1b overexpression is safe and efficacious and may be a candidate preventive therapy, we compared ST hippocampal FKBP1b overexpression with LT FKBP1b overexpression, which is initiated in midlife when memory impairment first begins to emerge (Forster and Lal, 1992; Gallagher and Rapp, 1997; Markowska, 1999; Wyss et al., 2000; Bizon et al., 2009; Scheinert et al., 2015).