KRAS and neoplasm: In the phase 2 Medical Research Council (MRC) COIN-B trial,16 patients who had metastatic KRAS wild-type tumours were treated with an intermittent strategy of oxaliplatin, intravenous fluorouracil, and folinic acid and randomised to either intermittent cetuximab (with intermittent chemotherapy) or continuous cetuximab (including single-agent maintenance through the interval between chemotherapy).