IGHE and allergic disease: In allergic diseases the targets against which biological agents have been developed are: IgE, Th2-response cytokines, such as IL-4, IL-5, IL-9, IL-13, IL-31, and TSLP, CCR4 chemokine receptor, and surface adhesion molecules CD2, CD11a, CD20, CD25, CD52, and ligand OX40.