Patients with a higher baseline level of T cells infiltrating the tumor (T cell-inflamed tumors) compared to non-responsive tumors (cold tumors) were more likely to respond to anti-CTLA-4 or anti-PD-1 therapies [54], and patients resistant to anti-PD-1 therapy had higher baseline levels of tumor-infiltrating MDSCs compared to responders [55]. The gene discussed is CTLA4; the disease is neoplasm.