LLC cells injected into Argflox/flox; Tie2-Cre+ mice (Fig. 3b, indicated as ARG1ΔM) grew smaller tumors that were similar in size to CB-1158-treated Argflox/flox; Tie2-Cre− mice (Fig. 3b, indicated as ARG1WT), and CB-1158 treatment of Argflox/flox; Tie2-Cre+ animals conferred no further reduction in tumor growth, consistent with specific on-target inhibition of Arg1 by CB-1158 (Fig. 3b). This evidence concerns the gene ARG1 and neoplasm.