Interestingly, NK cells and inflammatory (M1-type, CD80+) macrophages were significantly increased, while immunosuppressive (M2-type, CD206+) macrophages were significantly reduced in tumors of animals treated with the combination of CB-1158 and gemcitabine, indicating an increase in inflammation and a decrease in immune suppression in the tumor microenvironment (Fig. 7b). Here, MRC1 is linked to neoplasm.