High TC, HDL-C, and apo(a) levels were all associated with a reduction in total cancer mortality (Q4 vs. Q1, crude models, HRTC 0.71, HRHDL-C 0.56, HRapo(a) 0.64, Q4 cut-offs 6.60, 1.70, and 1.90, respectively; Table 2, Fig. 2). This evidence concerns the gene AOPEP and cancer.