Using the clinical cut-points for TC ≥ 6.18, HDL ≤ 1.03, apo(a) ≤ 1.05, apoB ≥ 1.56, TG ≥ 2.26, and Lp(a) ≥ 120, high TG and Lp(a) levels were associated with risk of stroke and high TC, TG, apoB, and Lp(a) levels with risk of MI after multivariable adjustment in comparable strength to quartile analyses mirroring these cut-points (Additional file 9). This evidence concerns the gene APOB and Stroke.