Multivariable adjustments for body height, waist circumference, BMI, lifetime alcohol consumption, intake of red meat and fiber, smoking habits, socioeconomic status, physical activity, diabetes, hypertension, and use of lipid-lowering drugs had negligible effects on the associations of apoB-100 or TG with risk of breast cancer but attenuated the direct associations of high apo(a) levels with breast cancer risk to non-significance, resulting in significant direct associations of high HDL-C levels with risk of breast cancer (HR 1.39, Q4 cut-off 1.90). The gene discussed is AOPEP; the disease is Hypertension.