It was reported that miR-381 was up-regulated in mouse liver and acted as a hub regulators [30], miR-142-3p can suppresses the migration and invasion of HCC cells by regulating RAC1 [31], and miR-214 can suppress invasion, stem-like traits and recurrence of HCC through targeting beta-catenin pathway [32]. The gene discussed is RAC1; the disease is hepatocellular carcinoma.