However, when we examined the key HRR protein, RAD51, we found that levels unexpectedly decreased by at least 65% in all five melanoma cell lines examined over a 3-day exposure to cisplatin, while levels in an ovarian cancer and a fibroblast cell line increased over the same period, as reported previously for lung cancer cell lines [24]. The gene discussed is RAD51; the disease is ovarian carcinoma.