RAD51 and melanoma: Although there was some heterogeneity in the timing of the RAD51 response of the melanoma cell lines, with C32 in particular showing an initial 2-fold increase at 24 h with the higher cisplatin concentrations, all showed the same major reduction in RAD51 levels seen previously in A375 after 72 h of 1 and 3 μM cisplatin treatment (>65% reduction at 3 μM).