Whereas, most of the ER+ breast tumors are found in post-menopausal women (~80%), and the normal range of DHT and E2 in postmenopausal women is 30-62pM/L and 55-220 pM/L, respectively, but at the same time DHT is increased, and E2 is decreased in ERα+ breast cancer patients on the AIs anastrozole [30, 31]. This evidence concerns the gene ESR1 and breast cancer.