Tumor cells undergoing EMT have reduced intercellular adhesion, with decreased E-cadherin expression or β-catenin translocation and increased expression of mesenchymal markers such as vimentin, fibronectin, and N-cadherin [41], which is reversible and is typically believed to promote invasiveness, metastasis, resistance to chemotherapeutic agents, and sometimes, EMT could induce the emergence of cancer stem cell (CSC) phenotypes in cancers including PDAC [36, 41]. Here, FN1 is linked to cancer.