· RAS-induced inhibition of cellular PKR is responsible for preferential activity in RAS-activated cells, allowing viral translation, replication, oncolysis and cancer cell death [8].· RAS activated JNK and NFkB can mediate reovirus- induced apoptosis [218, 219].· Reovirus can induce antitumor immune responses [14].· Reovirus can preferentially infect and kill pancreatic cancer cells [116, 117]. Here, EIF2AK2 is linked to familial pancreatic carcinoma.