· Adenovirus chimeras· Ad5-D24: serogroup 5, E1A-/Rb-binding site negative; selectively kills cells with an abnormal p16/Rb pathway [195]· CRAd: Ad5-D24 plus serogroup 3 knob [196]· DNX-2401: Ad5-D24 plus RDG (integrin receptor) [197]· Ad5/3-D24-GMCSF and CGTG-102: CRAd and DNX-2401 plus GM-CSF respectively [197, 198].· ColoAd1: tumor selective Adenovirus 11/3· Ad5/3, hTERT and CD40 ligand expressing strain has improved antitumor immunity/activity [18]. Here, RB1 is linked to neoplasm.