Compared with CRT, the addition of an anti-EGFR agent to RT or CRT showed trends for worse PFS (HR = 1.38 [95% CI: 0.86–2.21], P = 0.18) and OS (HR = 1.39 [95% CI: 0.90–2.13], P = 0.14) in patients with p16-positive LA-HNSCC (Figure 5). The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.