AFAP1-AS1 was significantly associated with distant metastasis in lung cancer (OR = 2.24; 95% CI: 1.08–4.67), colorectal cancer (OR = 7.50; 95% CI: 2.01–28.05), and esophageal cancer (OR = 2.98; 95% CI: 1.28–6.97) but not in liver cancer (OR = 3.33; 95% CI: 0.78–14.23). Here, AFAP1 is linked to liver cancer.