In conclusion, our results suggested that: (1) CD40 -1C>T (rs1883832) is associated with decreased risk of Graves’ disease (GD), especially in Asian; (2) CD40 -1C>T (rs1883832) is associated with increased risk of MS (multiple sclerosis); (3) CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto's thyroiditis (HT), systemic sclerosis (SSc) or Asthma; (4) there is insufficient data to fully confirm the association between CD40 -1C>T (rs1883832) and SLE, RA, BD, MG, CD, UC, Sarcoidosis, FUS, VKH, KD, GCA or ITP, and the results should be interpreted with caution. This evidence concerns the gene CD40 and temporal arteritis.