In conclusion, our results suggested that: (1) CD40 -1C>T (rs1883832) is associated with decreased risk of Graves’ disease (GD), especially in Asian; (2) CD40 -1C>T (rs1883832) is associated with increased risk of MS (multiple sclerosis); (3) CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto's thyroiditis (HT), systemic sclerosis (SSc) or Asthma; (4) there is insufficient data to fully confirm the association between CD40 -1C>T (rs1883832) and SLE, RA, BD, MG, CD, UC, Sarcoidosis, FUS, VKH, KD, GCA or ITP, and the results should be interpreted with caution. The gene discussed is CD40; the disease is rheumatoid arthritis.