MAD2 expression is regulated by a diverse range of cancer-associated proteins including the tumour suppressor protein p53, breast cancer 1 (BRCA1), the c-MYC oncogene, the checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (CHFR), E2 factor (E2F) and numerous microRNAs [10–16]. The gene discussed is MAD2L1; the disease is cancer.