FHIT and cancer: The kidney cancer results (ref 39 & Figure 4A) where the mutation burdens are low in smoking associated and non-associated cancers, with signature 5 as the main signature observed (Figure 4), is satisfying at the genetic level since the FHIT gene was originally cloned from cells of an individual at high risk for multifocal, bilateral clear cell kidney cancer that occurred in family members carrying an inherited, balanced chromosome translocation between chromosomes 3 & 8, where the chromosome 3 translocation break was within the fragile FRA3B locus, interrupting the FHIT gene [1].