Alexandrov et al [10], by 2013, had analyzed >5 million mutations in >7000 cancers, from which they extracted distinct mutational signatures, some of which were observed in many cancer types, including: two signatures, 2 & 13, attributed to the APOBEC family of cytidine deaminases; signature 1 associated with patient age at cancer diagnosis; signatures 4, 7, 11 associated with known mutagenic exposures; signatures 3, 6, 10 associated with mutations in DNA repair proteins, known as genome caretakers. This evidence concerns the gene CDA and cancer.