FHIT and lung adenocarcinoma: Also, Waters et al [9] showed that FHIT-low/APOBEC3B(A3B)-high cytidine deaminase-expressing lung adenocarcinomas displayed increased numbers of A3B signature mutations, while tumors with normal FHIT expression did not exhibit A3B hypermutation, in spite of high A3B expression; thus, A3B overexpression and Fhit-loss induced DNA damage are independent events that when occurring together, result in increased A3B induced mutations.