Table 1 lists the genes with SCNAs that were negatively or positively associated with mutational signature 5 in the 6649 cancer samples, identifying FHIT as the gene exhibiting the most significant, and negative, correlation with mutational signature 5 (Spearman p= 2.00E-65, MM Regression p= 1.90E-25); i.e., FHIT copy loss (negative GISTIC2 scores) was associated with higher density of signature 5 substitutions in the genomes of cancer cells. The gene discussed is FHIT; the disease is cancer.