To determine whether loss of FHIT, or 86 other cancer-relevant or cancer-driver genes [23, 24] (see Supplementary Table 1 for gene list), may be associated with the reported prevalence of mutational signature 5 in human cancers, we compiled the Somatic Copy Number Alterations (SCNAs) of FHIT and the other 86 cancer genes in The Cancer Genome Atlas (TCGA) samples (n=6649) previously characterized for mutational signatures. Here, FHIT is linked to cancer.