Treatment of THP-1 and U937 cells with NSC-743380 at 0.1 to 3 μM triggered obvious cleavage of caspase 3, caspase 8, and poly(ADP-ribose) polymerase (PARP), demonstrating that NSC-743380 induced robust apoptosis in AML cells. Here, CASP3 is linked to acute myeloid leukemia.