Mechanistic characterization revealed that NSC-743380 and its analogues induced apoptosis [11, 12], inhibited phosphorylation of the C-terminal domain of RNA polymerase II [10, 13], induced sustained JNK activation by inhibiting its dephosphorylation [14], induced intracellular reactive oxygen species (ROS) accumulation [15, 16], inhibited STAT3 phosphorylation, and suppressed cyclin D1 expression [11], suggesting that NSC-743380 modulates multiple cancer-related targets. Here, STAT3 is linked to cancer.