Intriguingly, we did not found NSC-743380 induced cFLIP changes in lung cancer cell H460, which is sensitive to NSC-743380 (data not shown) [11, 12], suggesting that the mechanisms of NSC-743380 mediated apoptosis in AML cells might be different from those observed in lung cancer cells [11, 12]. The gene discussed is CFLAR; the disease is lung cancer.