SULT1A1 and cancer: Upon correlation analysis of the anti-cancer activity of NSC-743380 and the gene expression levels in NCI-60 cell lines as well as functional characterization of the top genes associated with NSC-743380–mediated anticancer activity, we recently reported that expression of the sulfotransferase SULT1A1, a biotransformation enzyme that bioactivates a number of pro-carcinogens [17], is causally associated with the selective anti-cancer activity of NSC-743380 [18].