in vitro and in vivo downregulation of cFLIP with an antisense phosphorothioate oligonucleotide resulted in caspase 8 activation and apoptosis in cancer cells derived from lung, colorectal, and prostate cancer but not in normal cells or in cancer cells sensitized to TRAIL-induced and chemotherapy-induced apoptosis [37]. The gene discussed is CASP8; the disease is prostate carcinoma.