Our results demonstrated that NSC-743380 induces robust apoptosis and dramatic inhibition of cFLIP expression and of the expression and/or phosphorylation of multiple key nodes in the PI3K/AKT/mTOR pathway in some AML cells, suggesting that NSC-743380 and its analogues can be candidates for AML therapy. The gene discussed is CFLAR; the disease is acute myeloid leukemia.