PNPLA6 and endometrial cancer: Visual examination of the RNA-Seq data in IGV supports the premise that the NRAS and TP53 variants act as the driver mutations, as the only other variants identified by WGS which are transcribed in DL3 map to SPOP and PNPLA6. SPOP and PNPLA6 variants both occur at a frequency of less than 1% in endometrial cancers in COSMIC; PNPLA6 is reported in the TCGA dataset as a passenger mutation in endometrial cancer.