IFIT2 knockdown resulted in decreased apoptosis and increased tumor growth in vivo and vitro. Our results gave evidence that IFIT2 may be a downstream target gene of LncRNA00364-STAT3, and LncRNA00364 inhibits proliferation and promotes apoptosis through STAT3-IFIT2 axis in HCC. Here, IFIT2 is linked to hepatocellular carcinoma.