RNF187 and hepatocellular carcinoma: To delineate further the molecular basis by which RNF187 overexpression induces the invasion of HCC cells, whole genome transcriptome analysis on HCCLM3-control, HCCLM3-shRNF187, HepG2-control and HepG2-RNF187 cells were performed using RNA-seq (Figure 3A).