Univariate analysis revealed that tumor diameter, tumor differentiation, tumor numbers, microvascular/bile duct invasion, TNM stage and RNF187 expression were predictors for OS and DFS (Tables 2 and 3), In a multivariate Cox proportional hazards model, TNM stage and tumor differentiation were independent prognostic factor for OS; vascular invasion,TNM stage and tumor differentiation were independent prognostic factor for DFS. Here, RNF187 is linked to neoplasm.