Since there was a correlation between the expression of levels of RARRES3 and the translocation subtypes t(4;14) and t(11;14) and the fact that these subtypes are defined by overexpression of cyclin D2 and cyclin D1 respectively, we hypothesized that RARRES3 may mediate G1 arrest in MM during VS-5584 treatment by regulating cell cycle proteins. Here, PROS1 is linked to Miyoshi myopathy.