Even for the 21 patients with abnormal liver function (ALT level: median: 94 U/L, range: 54-244 U/L, n=21), the abnormality was self-limited and recovered within 3 months after surgery in most patients (90.4%, n=19) However, 2 cetuximab–treated patients did progress to hepatic failure and mortality after surgery. The gene discussed is GPT; the disease is liver failure.