Additionally, regulation of several genes implicated in cell-ECM interactions was observed and included repressed fibulin-1, an extracellular matrix (ECM) protein affecting Erk-mediated signaling cascades thereby inhibiting motility and invasiveness of cancer cells [54] and Lama3&4, e.g. ECM glycoprotein also shown to be repressed in various human cancers [55]. Here, MAPK1 is linked to cancer.