Finally, several of the novel c-Myc targets are interesting candidates for the development of molecularly targeted therapies, and this include inhibition of the highly up-regulated genes in lung cancer tissues such as Spint1, Ros1, Adora2b, Gjb3, amphiregulin and Adam19 which were also highly expressed in human tumor tissues as protein. The gene discussed is AREG; the disease is lung carcinoma.