In summary, our work provides evidence that IL-6/STAT3 pathway increases miR-92a expression by directly targeting the miR-92a promoter, resulting in Wnt/β-catenin signaling activation by targeting KLF4, GSK3β, and DKK3, and consequently promoting stem-like phenotypes of CRC cells. This evidence concerns the gene KLF4 and colorectal carcinoma.