As shown in Figure 6F, knockdown of STAT3 suppressed Wnt/β-catenin signaling by downregulation of nuclear translocation of β-catenin, decreased TOP/FOP luciferase reporter activity (Figure 6G) and sphere-forming capacity in CRC cells (Figure 6H), while these suppressive effects could be rescued by miR-92a. Here, STAT3 is linked to colorectal carcinoma.