CCDC69 and ovarian cancer: A2780cis CCDC69-/- #26 cells had 2.5-fold lower IC50 of cisplatin than A2780cis wildtype cells (p <0.001) (Figure 2A), suggesting that depletion of CCDC69 resensitized the cisplatin-induced cytotoxicity in the cisplatin-resistant ovarian cancer cells.