During the previous study, we had successfully cloned a gene, called Homo sapiens familial acute myelogenous leukemia related factor (FAMLF), from a FAB-M2 patient's bone marrow sample of a large AML pedigree with 11 cases in four consecutive generations, which was the second largest AML pedigree around the world [11, 12]. The gene discussed is MIR181A1HG; the disease is acute myeloid leukemia.