Consistent with the oncogenic function of SLC25A22 in CRC, knockdown of SLC25A22 down-regulated the biosynthesis of TCA cycle metabolites and Asp-derived amino acids (Ala, Asp and Gly) that are up-regulated in CRC, which in turn, impair KRAS-mutant CRC cell growth. The gene discussed is KRAS; the disease is colorectal carcinoma.