GPD1 and cancer: The GPD1 mRNA levels were significantly downregulated in tumours with a shallow deletion of GPD1 compared to those without such changes, including breast invasive carcinoma, brain lower-grade glioma, lung squamous cell carcinoma, ovarian serous cystadenocarcinoma, pancreatic adenocarcinoma and sarcoma (p < 0.05, Figure 6A and Supplementary Figure 6), suggesting that GPD1 deletion results in reduced GPD1 mRNA expression in these cancers.