Indirect evidence for a relationship come from some controlled clinical trials analyzing the role of physical activity and body weight in BRCA1/2 mutation carriers; Bordelau [25] demonstrated that risk for breast cancer is lower in BRCA1/2 carriers physically active and with lower weight; moreover, Kotsopoulos [26] showed in a case control study that weight loss and avoiding weight gain both reduced breast cancer risk among BRCA1/2 carriers. The gene discussed is BRCA1; the disease is breast cancer.