Results showed that a short overall survival time in patients with colon cancer is significantly correlated with a high percentage of GPC1+ plasma exosomes one day before (Figure 4A) and one week after (Figure 4B) surgery (p<0.001), and low plasma miR-96-5p (Figure 4C, 4D) (p<0.05) and low plasma miR-149 (Figure 4E, 4F) (p<0.05, p<0.01) levels one day before (Figure 4C, 4E) and one week after (Figure 4D, 4F) surgery. This evidence concerns the gene GPC1 and malignant colon neoplasm.