PDCD4 and esophageal squamous cell carcinoma: In this study, we report that KHSRP exerts oncogenic activity in ESCC cells, at least partly, by inducing the expression of a set of oncogenic miRNAs, including miR-21, miR-130b, and miR-301a, and by suppressing the downstream inhibitors of epithelial-to-mesenchymal transition (EMT), such as BMP6, PDCD4, and TIMP3, resulting in the malignant progression of this disease.