Both univariate and multivariate Cox regression analyses revealed that RUNX3 expression was an independent prognostic marker for RCC patient OS (univariate: hazard ratio 0.320, 95% CI 0.165-0.621, P=0.001; multivariate: hazard ratio 0.315, 95% CI 0.163-0.607, P=0.001) and DSS (univariate: hazard ratio 0.173, 95% CI 0.078-0.383, P<0.001; multivariate: hazard ratio 0.182, 95% CI 0.083-0.398, P<0.001) (Tables 2 & 3). The gene discussed is RUNX3; the disease is renal cell carcinoma.