In addition, Coue’ et al demonstrated that in human skeletal muscle GC-A expression positively correlates with insulin sensitivity whereas the expression of the NP clearance receptor is inversely related to this metabolic parameter.[26] Moreover, chronic infusion of BNP improved glucose tolerance and peripheral insulin sensitivity in a rodent model of obesity and diabetes. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.