Importantly, caspase-1 activation was also reduced by ~50% in pearl DCs after STm infection, as measured by the percentage of cells labeled by the fluorescent active caspase-1 probe FAM-YVAD-FMK (FLICA; Fig 2G), despite no reduction in pro-caspase-1 expression in these cells (Fig 1C and 1D). The gene discussed is CASP1; the disease is infection.