DES and familial dilated cardiomyopathy: In the DCM-cohort, pathogenic mutations were identified in DES, LMNA, and RBM20 (Table 1, S5 Table), whereas likely pathogenic mutations were found in MYL2, MYH7, TTN, TNNC1, DES, LMNA, RBM20, NEXN, and PKP2. Remarkably, a homozygous PKP2-gene mutation (c.2035C>T, p.His679Tyr) was identified in a large Turkish family (DCM-23).