More recently, Lussier et al. demonstrated that the combination of anti-PD-L1 and anti-CTLA-4 antibodies provided complete control of metastasis in subcutaneously inoculated K7M2 osteosarcoma mice, despite the lack of any such effect when only anti-CTLA-4 antibody was administered [32]. This evidence concerns the gene CTLA4 and osteosarcoma.