However, by using pathway enrichment and post-GWAS analyses, we identified five interesting genes that could be involved in the pathogenesis of CRSwNP in this study: HLCS, HLA-DRA, BICD2, VSIR and SLC5A1. Of these, only HLA-DRA has been presented in previous studies on subjects with CRSwNP [36]. Here, VSIR is linked to chronic rhinosinusitis with nasal polyps.