The majority of the deposited crystal structures and peptides eluted from H-2Db+ cells comprise an asparagine at position 5 in the peptides as preferred anchor residue for C pocket [53] with exceptions such as the recently identified cancer-associated TEIPP neo-epitope Trh4, that is presented exclusively on antigen processing deficient cells [55–57], and a mutated version of the influenza A epitope NP366 [58]. This evidence concerns the gene CERS5 and cancer.