PEX2 and peroxisomal disease: Because PEX2 has been implicated in peroxisome biogenesis (Gootjes et al., 2004), and peroxisome biogenesis disorders (PBDs) are typically associated with impaired lipid metabolism and CNS myelin defects (Krause et al., 2006), this prompted us to further explore a potential link between LRP1 and peroxisomes.