As our previous study reported, the TIMP2-based recombinant protein LDP-TIMP2 (LT) and its enediyne-integrated analog LDP(AE)-TIMP2 (LTE) that targets MMP-14/MMP-2 were effective against human esophageal carcinoma xenograft model in nude mice (Xu et al., 2015). This evidence concerns the gene TIMP2 and carcinoma of esophagus.