Its expression appears to be associated with chromatin relaxation or destabilization, as observed in mouse ES cells in which the chromatin assembly factor (CAF-1) Chaf1a is downregulated and in myoblasts from patients with FSHD (Geng et al. 2012; Ishiuchi et al. 2015). The gene discussed is CHAF1A; the disease is Facioscapulohumeral dystrophy.