In summary, we reported herein that stabilized β-catenin partly relieved the augments of splenic lymphocytes, the inflammation, and the lupus nephritis of Fas-mutation-mediated ALPS-like manifestations of lpr/lpr mice, especially suppressed the DNT (TCRβ+CD4−CD8−) and TEM cells, and declined the levels of some serum inflammation cytokines and chemokines most likely via Fas-independent signal pathway-mediated apoptosis. Here, FAS is linked to autoimmune lymphoproliferative syndrome.