In contrast, third-generation TKIs such as osimertinib, WZ4002, and CO-1686 bearing an anilinopyrimidine core, showed high potency and selectivity for EGFR L858R/T790M over WT EGFR, therefore serving as mutant-selective TKIs targeting EGFR mutants involved in NSCLC (Zhou et al., 2009; Walter et al., 2013; Cross et al., 2014; Finlay et al., 2014; Gray and Haura, 2014). Here, EGFR is linked to non-small cell lung carcinoma.