In the CRMO group, serum protein levels were above the levels in sera from healthy controls for the following parameters: CCL4/MIP-1β, CCL5/RANTES, IL-6, S100A8, sIL-2R, IL-1RA, IL-10, and collagen Iα (Figure S1 in Supplementary Material). This evidence concerns the gene CCL4 and chronic recurrent multifocal osteomyelitis.